Regional Gray Matter Volume Reduction Associated with Major Depressive Disorder: A Voxel-Based Morphometry

Major depressive disorder (MDD) is a typical and serious mental disorder such that lifetime prevalence reaches up to 16%, and 12-months prevalence is about 6.6%, and present various symptoms, including behavioral, cognitive, and emotional manifestations (1-3). The associations between the low emotional regulation which is the key feature of depressed patients and the structural changes such as the orbital and medial prefrontal cortices, amygdala, hippocampus, and related parts of the striatum This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: December 10, 2014 Revised: March 20, 2015 Accepted: March 25, 2015